Weight loss drugs like Ozempic, Wegovy, and Zepbound continue to be in short supply.
The weekly semaglutide or tirzepatide injectables for diabetes and weight loss are often praised by patients for the significant impact they can have.
“I was hardly mobile, I wanted to sleep all the time, I wanted to eat all the time, I didn’t want to go anywhere, it just hurt to move. I’ve gotten a second chance at life, and I’m not going to mess it up,” Ozempic patient Jacque Long said.
Some patients are now struggling to find pharmacies that can fill their prescription or going without. Since the drugs are still relatively new, we don’t have much long-term research yet on the potential impact. But doctors do know that abrupt cessation or restarting higher doses after a break can lead to further struggles.
Dr. Frank Chae advises that patients should be gradually weaned off these types of drugs — as abruptly stopping can be dangerous.
“It’s not like you can stop your therapeutic dose, and then go back to it a week or two later. The dire consequences are increased side effects, GI upsets like nausea and vomiting, diarrhea, constipation that can actually increase if this is stopped abruptly,” said Dr. Chae.
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Blood sugar spikes and intense carb cravings can also occur, he says. He recommends that when patients resume taking the drug, they should start with the smallest dose again.
Health care company Ro recently launched a public crowd-sourced shortage tracker to assist patients. The company also shares patient-reported shortages with the FDA.
Chae suggests that some patients could discuss off-label use of other medications, like liraglutide injections (such as Trulicity, for example), based on their existing conditions.
Patients may also consider trying compounded semaglutide. However, Chae advises caution with compounded drugs as their safety is not regulated by the FDA.
“The state of Mississippi, North Carolina, and West Virginia have banned these compounded drugs,” he said.
In conclusion, if you are considering suddenly stopping one of these drugs, it is important to consult with your healthcare provider first.
